Effects of Phellinus linteus on Brain Injury in Rats
Author Information
Author(s): Sakiko Suzuki, Takakazu Kawamata, Yoshikazu Okada, Tomonori Kobayashi, Tomoyuki Nakamura, Tomokatsu Hori
Primary Institution: Tokyo Women's Medical University
Hypothesis
Can Phellinus linteus culture filtrate reduce infarct size in a rat model of cerebral ischemia?
Conclusion
Phellinus linteus culture filtrate significantly reduces cortical infarct volume in a rat model of focal cerebral ischemia.
Supporting Evidence
- Pre-treatment with P. linteus culture filtrate significantly reduced cortical infarct volume.
- Post-treatment with the filtrate also showed significant effects on reducing infarct size.
- The higher molecular weight fraction of the culture filtrate was more effective than the lower molecular weight fraction.
Takeaway
This study found that a mushroom extract can help protect the brain from damage after a stroke, even if given after the stroke starts.
Methodology
Male Sprague-Dawley rats were treated with Phellinus linteus culture filtrate before and after inducing focal cerebral ischemia, and infarct volumes were measured 24 hours later.
Potential Biases
Potential bias in treatment assignment and measurement due to lack of blinding in some procedures.
Limitations
The exact neuroprotective substances in P. linteus have not been identified.
Participant Demographics
Male Sprague-Dawley rats, 8 weeks old, weighing 270–330 g.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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