Mimivirus and its Fusion Proteins
Author Information
Author(s): Yoshida Takashi, Claverie Jean-Michel, Ogata Hiroyuki
Hypothesis
The study investigates the amino acid sequence of the Mimivirus R555 gene product and its homologs in various organisms.
Conclusion
The study concludes that the Mre11/Rad50 fusion proteins are abundant in viral metagenomes and suggest that viruses played a crucial role in their formation and propagation.
Supporting Evidence
- The R555 protein sequence is a fusion of Mre11-like and Rad50-like domains.
- Twelve additional cases of Mre11/Rad50 fusions were identified in various organisms.
- The phyletic distribution of these fusion proteins suggests lateral gene transfers across organisms.
Takeaway
Scientists found that a virus called Mimivirus has a special protein made from two parts that help fix DNA. This protein is also found in other living things, showing that viruses can share genes.
Methodology
The study used bioinformatics analysis and systematic database searches to identify and analyze the R555 protein and its homologs.
Limitations
The study does not provide specific limitations.
Digital Object Identifier (DOI)
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