Clostridium difficile Infection in Hospitalized Adults
Author Information
Author(s): Muacevic Alexander, Adler John R, Ishanvi Ishanvi, Patro Shubhransu, Sharma Vibha, Sandeep Chikkam, Mohapatra Smrutisree, Sabat Smaranita, Panigrahi Kumudini, Pathi Basanti Kumari
Primary Institution: Kalinga Institute of Medical Sciences, Bhubaneswar, IND
Hypothesis
What is the incidence and what are the risk factors for Clostridium difficile infection among adult patients admitted to a tertiary care hospital?
Conclusion
The study found a 9% incidence of Clostridium difficile infection among hospitalized adults, highlighting the importance of careful antibiotic use.
Supporting Evidence
- The incidence of CDI was found to be 9% among the study participants.
- 60% of patients had been exposed to broad-spectrum antibiotics during hospitalization.
- All CDI-positive cases had fecal leukocytes detected in their stool samples.
Takeaway
This study shows that some people in the hospital can get a bad tummy bug called Clostridium difficile, especially if they take strong antibiotics.
Methodology
A prospective observational study was conducted with 200 adult patients, collecting stool samples and relevant clinical data to analyze for C. difficile toxins.
Limitations
The study had a short duration and small sample size, and only used ELISA for CDI detection.
Participant Demographics
{"mean_age":46.49,"gender_distribution":{"male":60,"female":40},"prior_hospitalization":19,"underlying_diseases":22}
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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