Identification of a 170-kDa protein over-expressed in lung cancers
2001
Discovery of a Protein Linked to Lung Cancer
publication
Author Information
Author(s): Pincheira R, Chen Q, Zhang J-T
Primary Institution: Indiana University Cancer Center
Hypothesis
Is the 170-kDa protein over-expressed in lung cancers compared to normal tissues?
Conclusion
The study found that a 170-kDa protein is over-expressed in all types of human lung cancers.
Supporting Evidence
- The 170-kDa protein is identified as a subunit of translation initiation factor eIF3.
- p170 mRNA is expressed at higher levels in adult proliferating tissues and during development.
Takeaway
Researchers found a special protein that is more common in lung cancer than in healthy tissue, which might help us understand cancer better.
Methodology
The study involved cDNA cloning to identify the protein and analyze its expression in various tissues.
Digital Object Identifier (DOI)
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