Physiological influences on neurovascular coupling
Author Information
Author(s): Joel S. Burma, Damian M. Bailey, Nathan E. Johnson, James K. Griffiths, Josh J. Burkart, Clara A. Soligon, Elizabeth K. S. Fletcher, Raelyn M. Javra, Chantel T. Debert, Kathryn J. Schneider, Jeff F. Dunn, Jonathan D. Smirl
Primary Institution: University of Calgary
Hypothesis
How do physiological, psychological, and lifestyle factors influence neurovascular coupling during multimodal imaging studies?
Conclusion
The review highlights the need for better control of physiological and lifestyle confounders in neurovascular coupling research.
Supporting Evidence
- 364 articles were included following title/abstract and full-text screening.
- 92.9% of studies displayed an absence/minimal control of blood pressure and other physiological factors.
- Only 1.3% of studies monitored blood pressure, arterial gas concentrations, and heart rate.
Takeaway
This study looks at how different factors like blood pressure and exercise affect how our brain blood flow responds when we think or do tasks.
Methodology
The review included original research articles that used concurrent neuronal and haemodynamic quantification in humans during task paradigms.
Potential Biases
High risk of bias due to minimal control of confounding factors in most studies.
Limitations
The majority of studies had inadequate control for physiological influences and confounding factors.
Participant Demographics
The average number of participants was 24.8, with 42.6% female representation.
Digital Object Identifier (DOI)
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