Fgf20 Signalling Induces the Switch from Neurogenesis to Oligodendrogenesis in Zebrafish
Author Information
Author(s): Tim J. Yeung, David G. Wilkinson
Primary Institution: The Francis Crick Institute
Hypothesis
Fgf20 signalling patterns progenitors to induce the switch from neurogenesis to oligodendrogenesis in the zebrafish hindbrain.
Conclusion
Fgf20 signalling from earlier-born neurons spatially and temporally patterns hindbrain segments to induce the neurogenesis-to-oligodendrogenesis switch.
Supporting Evidence
- Fgf20 signalling inhibits neurogenesis by downregulating proneural gene expression.
- Fgf20 induces oligodendrocytes by upregulating olig2 and sox10 expression in progenitors.
- Overexpression of fgf20a leads to increased oligodendrocyte production at the expense of neurogenesis.
Takeaway
Fgf20 is like a signal that tells certain brain cells when to stop making neurons and start making a different type of cell called oligodendrocytes, which help support neurons.
Methodology
The study used hybridisation chain reaction (HCR) RNA fluorescence in situ hybridization (RNA-FISH) to measure gene expression with high spatial resolution.
Digital Object Identifier (DOI)
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