Localization of the Cochlear Amplifier in Living Sensitive Ears
2011

Location of the Cochlear Amplifier

Sample size: 30 publication Evidence: moderate

Author Information

Author(s): Ren Tianying, He Wenxuan, Porsov Edward

Primary Institution: Oregon Health & Science University

Hypothesis

The cochlear amplifier is thought to be a local cellular process at an area basal to the response peak on the spiral basilar membrane.

Conclusion

The cochlea amplifier resides at a small longitudinal region basal to the response peak in the sensitive cochlea.

Supporting Evidence

  • The cochlea can boost soft sound-induced vibrations as much as 50 dB/mm.
  • The amplification works maximally at low sound levels and at frequencies immediately below the peak-response frequency.
  • The amplification decreases more than 65 dB/mm as sound levels increase.

Takeaway

The cochlea helps us hear soft sounds by amplifying them in a specific area, making it easier for us to detect quiet noises.

Methodology

The study used a sensitive laser interferometer to measure vibrations at two locations along the basilar membrane in sensitive gerbil cochleae.

Limitations

Data acquisition efficiency was low due to high-frequency hearing loss and poor visibility of cochlear fluid.

Participant Demographics

Thirty healthy young Mongolian gerbils (40–80 g) were used in this study.

Digital Object Identifier (DOI)

10.1371/journal.pone.0020149

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