Taste Masked Microspheres of Ofloxacin for Orodispersible Tablets
Author Information
Author(s): Malik Karan, Arora Gurpreet, Singh Inderbir
Primary Institution: Chitkara University
Hypothesis
The study aimed to develop taste masked microspheres of ofloxacin using Eudragit and prepare orodispersible tablets with a natural superdisintegrant.
Conclusion
The study concluded that Eudragit polymers effectively mask the bitter taste of ofloxacin, and locust bean gum can be used as a natural superdisintegrant in orodispersible tablets.
Supporting Evidence
- The microspheres showed an entrapment efficiency ranging from 69.54% to 86.52%.
- In vitro ofloxacin release was about 97.25% within 2 hours.
- The wetting time of the tablets ranged from 10 to 19 seconds.
Takeaway
This study created a new type of medicine that doesn't taste bad, making it easier for kids and older people to take their medicine.
Methodology
Microspheres were prepared using solvent evaporation technique, and orodispersible tablets were formulated using locust bean gum as a superdisintegrant.
Participant Demographics
Healthy male volunteers
Digital Object Identifier (DOI)
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