Gene Alterations in Breast Cancer: Differences Between Young and Older Women
Author Information
Author(s): Sinha Satyabrata, Singh Ratnesh, Alam Neyaz, Roy Anup, Roychoudhury Susanta, Panda Chinmay Kumar
Primary Institution: Chittaranjan National Cancer Institute, Kolkata, India
Hypothesis
Younger women with breast carcinoma exhibit different molecular alterations compared to older women.
Conclusion
Alterations in the genes PHF2, FANCC, and PTCH1 are more frequent in breast cancer cases, indicating their potential role as prognostic markers.
Supporting Evidence
- 91% of samples showed alterations in at least one of the candidate genes.
- FANCC alterations were significantly associated with poor patient survival.
- Alterations in PTCH1 and XPA were also linked to adverse outcomes in younger women.
- High deletion rates were observed in PHF2, FANCC, and PTCH1 compared to XPA.
Takeaway
This study looked at how certain genes change in younger and older women with breast cancer, finding that younger women often have more aggressive forms of the disease.
Methodology
The study analyzed gene alterations in 106 breast cancer samples from patients, comparing early-onset (≤ 40 years) and late-onset (> 40 years) cases using deletion analysis, methylation analysis, and expression studies.
Limitations
The study is limited to a specific population and may not be generalizable to other ethnic groups.
Participant Demographics
Patients included 104 unrelated individuals undergoing surgery at a cancer institute in Kolkata, India.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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