Abnormalities of the FHIT gene in human oral carcinogenesis
2000
FHIT Gene Changes in Oral Cancer
Sample size: 15
publication
Evidence: moderate
Author Information
Author(s): Tanimoto K, Hayashi S, Tsuchiya E, Tokuchi Y, Kobayashi Y, Yoshiga K, Okui T, Kobayashi M, Ichikawa T
Primary Institution: Hiroshima University School of Dentistry
Hypothesis
Is the FHIT gene a frequent target for alteration during oral carcinogenesis?
Conclusion
The study found that alterations in the FHIT gene are involved in the development of oral cancer.
Supporting Evidence
- Abnormal FHIT transcripts were found in eight of 15 oral SCCs.
- Deletion patterns of the FHIT gene were most common in the cancer samples.
- Abnormal FHIT transcripts were also observed in two of seven premalignant lesions.
- One patient with a premalignant lesion developed oral SCC during a 3-year follow-up.
Takeaway
The FHIT gene can change in people with oral cancer, which might help us understand how this type of cancer develops.
Methodology
Tissue samples from oral squamous cell carcinomas and premalignant lesions were analyzed for FHIT gene abnormalities.
Digital Object Identifier (DOI)
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