Role of Pyrimidine Nucleoside Phosphorylase mRNA in Oesophageal Cancer Prognosis
Author Information
Author(s): Yamagata M, Mori M, Mimori K, Mafune K-I, Tanaka Y, Ueo H, Akiyoshi T
Primary Institution: Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
Hypothesis
The expression of pyrimidine nucleoside phosphorylase mRNA is a predictive factor for the prognosis of patients with oesophageal carcinoma.
Conclusion
Higher levels of pyrimidine nucleoside phosphorylase mRNA are associated with worse prognosis in oesophageal cancer patients.
Supporting Evidence
- A positive correlation was observed between the T/N ratio of PyNPase mRNA expression and enzyme activity.
- The T/N ratio was significantly higher in cases with lymph vessel invasion, lymph node metastasis, and advanced disease stage.
- Patients with a higher T/N ratio of PyNPase mRNA had significantly worse prognosis.
Takeaway
This study found that measuring a specific mRNA can help doctors predict how serious a patient's oesophageal cancer might be.
Methodology
The study examined the expression of PyNPase mRNA in tumours and normal tissues using reverse transcription polymerase chain reaction (RT-PCR).
Statistical Information
P-Value
P = 0.009
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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