Efficacy of NexGard® PLUS and Simparica Trio® against Heartworm Disease
Author Information
Author(s): Prullage Joseph, Frost Justin, DiCosty Utami, Martin Elizabeth, Dumont Pascal, Yoon Stephen, Süssenberger Ricarda
Primary Institution: Boehringer Ingelheim Animal Health
Hypothesis
How effective are NexGard® PLUS and Simparica Trio® in preventing heartworm disease caused by resistant and susceptible isolates?
Conclusion
NexGard® PLUS and Simparica Trio® are highly effective in preventing heartworm disease, with NexGard® PLUS showing 100% efficacy against a susceptible isolate.
Supporting Evidence
- NexGard® PLUS showed 99.5% efficacy against a resistant heartworm isolate.
- Simparica Trio® showed 99.8% efficacy against the same resistant isolate.
- NexGard® PLUS was 100% effective against a susceptible heartworm isolate.
Takeaway
This study shows that two medications can help prevent heartworm disease in dogs, even when the worms are resistant to some treatments.
Methodology
Two studies were conducted with dogs randomly assigned to treatment groups, receiving either NexGard® PLUS or Simparica Trio® over several months, followed by necropsy to assess heartworm presence.
Potential Biases
Potential bias due to the involvement of the manufacturer in the study design and funding.
Limitations
The studies were conducted in controlled environments, which may not fully represent real-world conditions.
Participant Demographics
Eighteen healthy Beagle dogs in study 1 and twenty healthy Beagle dogs in study 2, with a mix of male and female dogs.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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