Effects of Bifidobacterium adolescentis on Colon Cancer Cells
Author Information
Author(s): Lee Do Kyung, Jang Seok, Kim Mi Jin, Kim Jung Hyun, Chung Myung Jun, Kim Kyung Jae, Ha Nam Joo
Primary Institution: Sahmyook University
Hypothesis
The study aims to evaluate the growth inhibition of tumor cells by butanol extract of Bifidobacterium adolescentis.
Conclusion
The butanol extract of B. adolescentis SPM0212 may help prevent colon cancer by enhancing the immune system.
Supporting Evidence
- The butanol extract inhibited the growth of Caco-2, HT-29, and SW480 cells by 70%, 30%, and 40%, respectively.
- The extract increased TNF-α and NO production in macrophage cells.
- B. adolescentis SPM0212 showed direct anti-proliferative activity against colon cancer cell lines.
Takeaway
This study found that a substance from a type of good bacteria can help stop cancer cells from growing.
Methodology
The anti-proliferative activity was assessed using XTT assays on three human colon cancer cell lines and the effects on TNF-α and NO production were tested using RAW 264.7 macrophage cells.
Participant Demographics
Healthy young Koreans aged 20-30 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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