Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?
2011
How Reactive Oxygen Species Activate MAPK Pathways
publication
Evidence: moderate
Author Information
Author(s): Son Yong, Cheong Yong-Kwan, Kim Nam-Ho, Chung Hun-Taeg, Kang Dae Gill, Pae Hyun-Ock
Primary Institution: Wonkwang University School of Medicine
Hypothesis
The mechanisms by which reactive oxygen species (ROS) can activate MAPK pathways are unclear.
Conclusion
Reactive oxygen species can activate MAPK pathways through oxidative modifications of signaling proteins and inactivation of MAPK phosphatases.
Supporting Evidence
- Cellular stimuli that produce ROS can also activate MAPK pathways.
- Antioxidants block MAPK activation, indicating ROS involvement.
- Exogenous H2O2 activates MAPK pathways.
Takeaway
This study explains how certain molecules called reactive oxygen species can help activate important pathways in our cells that control growth and stress responses.
Limitations
The precise molecular targets of ROS in MAPK activation are unknown.
Digital Object Identifier (DOI)
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