Prognostic significance of positive peritoneal cytology in endometrial carcinoma
Author Information
Author(s): Kasamatsu T, Onda T, Katsumata N, Sawada M, Yamada T, Tsunematsu R, Ohmi K, Sasajima Y, Matsuno Y
Primary Institution: National Cancer Center Hospital
Hypothesis
What is the prognostic significance of positive peritoneal cytology in endometrial carcinoma confined to the uterus?
Conclusion
Positive peritoneal cytology is not an independent adverse prognostic factor in endometrial carcinoma confined to the uterus.
Supporting Evidence
- 280 patients were included in the study, with 48 having positive peritoneal cytology.
- The 5-year survival rate was 91% for the positive cytology group and 95% for the negative group.
- Histologic grade was found to be an independent prognostic factor, not positive cytology.
Takeaway
This study looked at women with a type of cancer called endometrial carcinoma and found that having cancer cells in the fluid around their abdomen didn't mean they would do worse than those without those cells.
Methodology
A retrospective clinicopathological study reviewing medical records and cytologic materials from 392 patients with surgically treated endometrial carcinoma.
Potential Biases
Potential bias due to the retrospective nature and the small number of patients receiving adjuvant therapy.
Limitations
The study is retrospective and the number of statistical events was limited.
Participant Demographics
Mean age of participants was 56 years, with a range from 27 to 81 years.
Statistical Information
P-Value
0.42
Confidence Interval
0.56–5.86
Statistical Significance
p=0.42
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website