6-Hydroxyflavanone Helps with Anxiety and Nerve Pain from Chemotherapy in Rats
Author Information
Author(s): Akbar Shehla, Subhan Fazal, Qamar Rida, Akbar Aroosha, Shahbaz Naila, Aamir Muhammad, Siddique Nayyer, Islam Salman Ul
Primary Institution: Department of Pharmacy, CECOS University of IT and Emerging Sciences, Peshawar, Pakistan
Hypothesis
Can 6-hydroxyflavanone treat chemotherapy-induced neuropathy and anxiety?
Conclusion
6-HF might be considered a potential therapeutic agent for counteracting two common adverse effects of chemotherapy, neurotoxicity and anxiety.
Supporting Evidence
- 6-HF significantly reduced chemotherapy-induced mechanical allodynia in rats.
- 6-HF increased the paw withdrawal threshold and latency in treated rats.
- 6-HF showed anxiolytic-like activity in various anxiety models.
- Rats treated with 6-HF spent more time in the open arms of the elevated plus maze.
- 6-HF reduced anxiety-like behavior without affecting locomotion.
Takeaway
This study found that a substance called 6-hydroxyflavanone can help reduce pain and anxiety caused by chemotherapy in rats.
Methodology
The study used male Sprague–Dawley rats to evaluate the effects of 6-HF on chemotherapy-induced neuropathy and anxiety through various behavioral tests.
Limitations
The study evaluated neuropathy and anxiety in the same animal model, which may limit the generalizability of the findings.
Participant Demographics
Male Sprague–Dawley rats, aged 8 weeks, weighing 150-250g.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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