Differential and antagonistic effects of 9- cis -retinoic acid and vitamin D analogues on pancreatic cancer cells in vitro
2000
Effects of Retinoic Acid and Vitamin D on Pancreatic Cancer Cells
publication
Author Information
Author(s): Pettersson F, Colston K W, Dalgleish A G
Primary Institution: St George’s Hospital Medical School
Hypothesis
How do 9-cis-retinoic acid and vitamin D analogues affect pancreatic cancer cells?
Conclusion
Both retinoic acids and vitamin D analogues inhibit pancreatic tumor cell growth, but they do so through different and opposing mechanisms.
Supporting Evidence
- All compounds caused inhibition of in vitro growth.
- Vitamin D analogues were generally more potent growth inhibitors.
- Growth arrest correlated with an increased proportion of cells in the G0/G1 phase.
- 9-cis-retinoic acid induced apoptosis in the three cell lines.
Takeaway
This study found that certain compounds can stop pancreatic cancer cells from growing, but they work in different ways.
Methodology
The study investigated the effects of 9-cis-retinoic acid and vitamin D analogues on three pancreatic adenocarcinoma cell lines in vitro.
Digital Object Identifier (DOI)
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