Expression of interleukin 6 (IL-6) correlates with oestrogen receptor in human breast carcinoma
1999
IL-6 and Breast Cancer
Sample size: 149
publication
Evidence: moderate
Author Information
Author(s): Fontanini G, Campani D, Roncella M, Cecchetti D, Calvo S, Toniolo A, Basolo F
Primary Institution: University of Pisa
Hypothesis
The study investigates the correlation between IL-6 expression and various clinico-pathological variables in breast carcinoma.
Conclusion
The study found that lower IL-6 expression is associated with more aggressive forms of breast cancer.
Supporting Evidence
- IL-6 expression was inversely associated with histological tumour grade.
- Ki67 positivity was inversely correlated with IL-6 expression.
- There was a direct association between IL-6-positive cells and oestrogen receptor-positive cells.
- There was a direct association between IL-6-positive cells and progesterone receptor-positive cells.
Takeaway
This study looked at a protein called IL-6 in breast cancer and found that less of it means the cancer is usually more serious.
Methodology
The expression of IL-6 was analyzed in 149 cases of invasive breast carcinoma and correlated with various clinico-pathological variables.
Statistical Information
P-Value
P = 0.0017
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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