Innate Immune Database (IIDB)
Author Information
Author(s): Korb Martin, Rust Aistair G, Thorsson Vesteinn, Battail Christophe, Li Bin, Hwang Daehee, Kennedy Kathleen A, Roach Jared C, Rosenberger Carrie M, Gilchrist Mark, Zak Daniel, Johnson Carrie, Marzolf Bruz, Aderem Alan, Shmulevich Ilya, Bolouri Hamid
Primary Institution: Institute for Systems Biology
Hypothesis
The IIDB aims to provide a comprehensive resource for understanding transcription factor binding sites and regulatory interactions in mouse innate immunity.
Conclusion
The IIDB serves as a valuable community resource for immunologists studying gene regulatory systems related to innate responses to pathogens.
Supporting Evidence
- The IIDB includes annotations for over 2000 genes, including over 1600 TLR-responsive genes.
- Over 50% of predicted binding sites for ATF3 coincide with experimental ChIP-chip results.
- The database allows users to analyze individual genes or entire genomic loci.
- Users can interactively interrogate IIDB using a web interface.
- IIDB integrates data from multiple sources, including microarray experiments and genomic databases.
Takeaway
The IIDB is like a big library that helps scientists find out how certain genes in mice respond to germs and what controls them.
Methodology
The database was constructed using data from over 150 microarray experiments and includes computational predictions of transcription factor binding sites.
Limitations
The database is currently limited to mouse genes and may not cover all aspects of immune responses.
Participant Demographics
The study focuses on C57/BL6 mouse bone marrow macrophages.
Statistical Information
P-Value
p<0.001
Digital Object Identifier (DOI)
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