CD24 Deletion Protects Against Autoimmune Diseases
Author Information
Author(s): Wang Lizhong, Lin Shili, Rammohan Kottil W, Liu Zhenqiu, Liu Jin-qing, Liu Run-hua, Guinther Nikki, Lima Judy, Zhou Qunmin, Wang Tony, Zheng Xincheng, Birmingham Dan J, Rovin Brad H, Hebert Lee A, Wu Yeeling, Lynn D. Joanne, Cooke Glenn, Yu C. Yung, Zheng Pan, Liu Yang
Primary Institution: University of Michigan
Hypothesis
Does a dinucleotide deletion in the CD24 gene reduce the risk of multiple sclerosis and systemic lupus erythematosus?
Conclusion
The study found that a specific deletion in the CD24 gene significantly reduces the risk and progression of multiple sclerosis and systemic lupus erythematosus.
Supporting Evidence
- The P1527del allele was associated with a significantly reduced risk of MS.
- Patients with the P1527del allele showed delayed progression of MS.
- The same polymorphism also conferred a reduced risk for systemic lupus erythematosus.
Takeaway
If you have a certain change in a gene called CD24, it can help protect you from getting some diseases where your body attacks itself, like multiple sclerosis and lupus.
Methodology
The study used case/control studies and family-based tests to analyze the association between CD24 polymorphisms and autoimmune diseases.
Participant Demographics
Caucasian participants with multiple sclerosis and systemic lupus erythematosus.
Statistical Information
P-Value
p = 0.002
Confidence Interval
0.34–0.82
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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