Antiviral Properties of Polysaccharides from Red Algae
Author Information
Author(s): Rhimou Bouhlal, Camille Haslin, Jean-Claude Chermann, Sylvia Colliec-Jouault, Corinne Sinquin, Gaelle Simon, Stephane Cerantola, Hassane Riadi, Nathalie Bourgougnon
Primary Institution: Laboratoire de Biotechnologie et Chimie Marines (LBCM), Université européenne de Bretagne
Hypothesis
Can sulfated polysaccharides from Sphaerococcus coronopifolius and Boergeseniella thuyoides inhibit the replication of HIV and HSV-1?
Conclusion
The study found that polysaccharides from both algae effectively inhibited the replication of HIV-1 and HSV-1 without affecting cell viability.
Supporting Evidence
- Polysaccharides from S. coronopifolius inhibited HIV-1 replication at 12.5 μg/mL.
- Polysaccharides from B. thuyoides inhibited HSV-1 replication with EC50 values of 4.1 and 17.2 μg/mL.
- The study highlights the potential of marine sulfated polysaccharides as antiviral agents.
Takeaway
This study shows that certain seaweed extracts can help stop viruses like HIV and herpes from making more copies of themselves.
Methodology
Polysaccharides were extracted from two red algae and tested for their ability to inhibit HIV-1 and HSV-1 replication in vitro.
Limitations
The study primarily focused on in vitro results, which may not fully translate to in vivo effectiveness.
Digital Object Identifier (DOI)
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