Cost-effectiveness of Colorectal Cancer Screening with Stool DNA Testing
Author Information
Author(s): Wu Grace Hui-Min, Wang Yi-Ming, Yen Amy Ming-Fang, Wong Jau-Min, Lai Hsin-Chih, Warwick Jane, Chen Tony Hsiu-Hsi
Primary Institution: National Taiwan University
Hypothesis
Is stool DNA testing a cost-effective screening method for colorectal cancer compared to other screening strategies?
Conclusion
Stool DNA testing is less cost-effective than other recommended screening strategies for colorectal cancer in countries with low or intermediate incidence.
Supporting Evidence
- Stool DNA testing every three years can reduce colorectal cancer mortality by 22%.
- Stool DNA testing every five years can reduce colorectal cancer mortality by 15%.
- Stool DNA testing every ten years can reduce colorectal cancer mortality by 9%.
- The cost per life-year saved for stool DNA testing is significantly higher than for other screening methods.
Takeaway
This study looked at different ways to check for colon cancer and found that using stool DNA tests isn't as good for saving money and lives as other methods.
Methodology
A Markov model was developed to evaluate various screening strategies for colorectal cancer in the general population aged 50 to 75 in Taiwan.
Limitations
The model assumes an adenoma to carcinoma sequence and does not account for non-polypoid colorectal cancer cases.
Participant Demographics
General population aged 50 to 75 years in Taiwan.
Digital Object Identifier (DOI)
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