How Viscum album Helps Activate Immune Cells in Cancer Therapy
Author Information
Author(s): Elluru Sri Ramulu, van Huyen Jean-Paul Duong, Delignat Sandrine, Kazatchkine Michel D, Friboulet Alain, Kaveri Srini V, Bayry Jagadeesh
Primary Institution: Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris
Hypothesis
The VA preparations induce activation of human dendritic cells that facilitates effective tumor regression.
Conclusion
The VA preparations stimulate the maturation and activation of human dendritic cells, which may facilitate anti-tumoral immune responses.
Supporting Evidence
- VA Qu Spez stimulated dendritic cells to express more co-stimulatory molecules.
- The extract induced the secretion of inflammatory cytokines IL-6 and IL-8.
- Dendritic cells treated with VA Qu Spez were able to stimulate T cell proliferation.
Takeaway
This study shows that a mistletoe extract can help immune cells in the body fight cancer better.
Methodology
Monocyte-derived immature dendritic cells were treated with Viscum album extract and analyzed for surface molecule expression and cytokine secretion.
Participant Demographics
Healthy donors' peripheral blood mononuclear cells were used.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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