Mesothelioma of the Peritoneum in England and Wales (1967-1982)
Author Information
Author(s): M.J. Gardner, R.D. Jones, E.C. Pippard, N. Saitohl
Primary Institution: Medical Research Council's Environmental Epidemiology Unit, University of Southampton
Hypothesis
What is the time-trend and geographical distribution of mesothelioma of the peritoneum in England and Wales from 1967 to 1982?
Conclusion
The study found an increase in mesothelioma cases of the peritoneum over the 16-year period, particularly in men, with geographical patterns linked to past asbestos use.
Supporting Evidence
- The annual number of mesothelioma cases rose from about 15-20 to about 30-50 over the study period.
- Men had double the number of cases compared to women, with similar trends observed for both sexes.
- High registration rates were found in areas with historical asbestos use, particularly on the east side of London.
Takeaway
This study looked at how many people got a type of cancer called mesothelioma in their belly over 16 years, and it found that more men got it than women, especially in places where asbestos was used a lot.
Methodology
The study analyzed records from the Mesothelioma Register, focusing on cases of peritoneal mesothelioma registered from 1967 to 1982, using data from various sources including death certificates.
Potential Biases
There is a risk of bias due to potential misdiagnosis of peritoneal mesothelioma as other abdominal cancers.
Limitations
The study may be limited by underdiagnosis of peritoneal mesothelioma and incomplete histological confirmation.
Participant Demographics
The study included 457 cases, with 305 (67%) in men and 152 (33%) in women, primarily affecting older adults.
Statistical Information
Statistical Significance
p<0.05
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