Linkage and Association Mapping of Brain Rhythms
Author Information
Author(s): Kraja Aldi T, Borecki Ingrid B, Province Michael A
Primary Institution: Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA
Hypothesis
Can the linkage results of previous studies be reproduced with the available data?
Conclusion
The study found a significant association between certain SNPs and brain rhythms, although the strength of the associations was reduced due to missing data.
Supporting Evidence
- The study included 1,000 subjects' phenotypes for linkage analysis.
- A haplotype of two SNPs showed a significant association with ecb21.
- The heritability of the trait ecb21 was found to be 68%.
Takeaway
The researchers looked at how genes might affect brain waves and found some links, but they couldn't confirm everything because some data was missing.
Methodology
Linkage analysis and SNP association tests were performed using data from the Collaborative Study on the Genetics of Alcoholism.
Limitations
The study was limited by missing phenotypic data for 614 subjects, which affected the strength of the findings.
Participant Demographics
The sample included 1,000 individuals from 354 nuclear families, predominantly Caucasian.
Statistical Information
P-Value
0.015
Statistical Significance
p = 0.015
Digital Object Identifier (DOI)
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