Kalanchoe crenata Improves Blood Pressure Control with Losartan
Author Information
Author(s): Amatto Pedro de Padua G., Coppede Juliana da Silva, Kitanishi Carla Renata, Braga Giovana Graça, de Faria Thaysa Carvalho, Rizzi Elen, França Suzelei de Castro, Basso Fernanda, Lopes Adriana Aparecida, Carmona Fábio, Contini Silvia Helena Taleb, Pereira Ana Maria Soares
Primary Institution: University of Ribeirão Preto
Hypothesis
Does Kalanchoe crenata enhance the antihypertensive effects of losartan?
Conclusion
The combination of Kalanchoe crenata extract and losartan effectively reduced blood pressure in hypertensive rats.
Supporting Evidence
- The study showed significant reductions in systolic blood pressure in the group treated with both K. crenata extract and losartan.
- Chemical markers of K. crenata were identified as patuletin derivatives.
- Hypertensive rats treated with K. crenata and losartan had blood pressure levels similar to normotensive controls.
Takeaway
This study found that a plant called Kalanchoe crenata can help a medicine called losartan work better to lower blood pressure in rats.
Methodology
The study used male Wistar rats with induced hypertension, treating them with K. crenata extract, losartan, or both for eight weeks.
Potential Biases
Potential interactions with other medications due to K. crenata's effects on drug metabolism were not fully explored.
Limitations
The study only tested one dose regimen and did not assess vascular reactivity or tonus.
Participant Demographics
Male Wistar rats aged 180-220 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website