Effect of Enrofloxacin on Bacteria in Calves
Author Information
Author(s): Boudewijn Catry, Siska Croubels, Stefan Schwarz, Piet Deprez, Bianca Cox, Corinna Kehrenberg, Geert Opsomer, Annemie Decostere, Freddy Haesebrouck
Primary Institution: Ghent University
Hypothesis
How does systemic fluoroquinolone administration affect the presence of Pasteurella multocida in the nasopharynx of healthy calves?
Conclusion
Enrofloxacin temporarily eradicated Pasteurella multocida in treated calves but allowed Arcanobacterium pyogenes to become predominant.
Supporting Evidence
- Enrofloxacin was administered at a dose of 5 mg/kg for five days.
- Pasteurella multocida was isolated from control calves throughout the study.
- Arcanobacterium pyogenes became predominant in one treated calf after enrofloxacin therapy.
Takeaway
When calves were given a medicine called enrofloxacin, it helped get rid of a bad germ for a while, but another germ took its place.
Methodology
Four calves were treated with enrofloxacin or placebo, and nasal samples were collected to monitor bacterial presence over 10 days.
Potential Biases
Potential bias due to the small number of calves and the controlled environment.
Limitations
The study had a small sample size and was limited to only two treatment groups.
Participant Demographics
Four dairy calves aged 24–28 days.
Statistical Information
P-Value
0.04
Statistical Significance
p=0.04
Digital Object Identifier (DOI)
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