Study of SBEM Protein in Breast Cancer
Author Information
Author(s): Skliris G P, Hubé F, Gheorghiu I, Mutawe M M, Penner C, Watson P H, Murphy L C, Leygue E, Myal Y
Primary Institution: University of Manitoba
Hypothesis
The study aims to investigate SBEM protein expression in invasive breast cancers and its relationship to clinical outcomes.
Conclusion
SBEM may identify a unique subset of breast cancers with poor prognosis and implications for treatment.
Supporting Evidence
- 18% of tumors were SBEM positive.
- SBEM was more frequently observed in ER- cancers than in ER+ cancers.
- SBEM expression was associated with higher tumor grade.
Takeaway
This study looked at a protein called SBEM in breast cancer to see if it can help doctors understand which cancers are more dangerous.
Methodology
Immunohistochemical analysis was performed on tissue microarrays of 300 invasive breast cancers.
Potential Biases
Potential bias in sample selection and interpretation of immunohistochemical results.
Limitations
The study may not fully represent all breast cancer types due to the specific cohort selected.
Participant Demographics
The study included 300 patients with invasive breast cancer, with a mix of ER+ and ER- cancers.
Statistical Information
P-Value
0.049
Confidence Interval
95% CI 0.29, 0.98
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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