Utility of Fundus Autofluorescence and Optical Coherence Tomography in Measuring Retinal Vascular Thickness, Macular Density, and Ophthalmic Manifestations in Women with Gestational Diabetes Mellitus
2024

Measuring Eye Health in Pregnant Women with Gestational Diabetes

Sample size: 34 publication 10 minutes Evidence: moderate

Author Information

Author(s): Al-Dwairi Rami, Altal Omar, Fares Marwa, Adi Sharaf H., Said Shahed A., Shurair Asmaa, Al-Bataineh Rania, Aljarrah Ihsan, Al Beiruti Seren, Al Sharie Ahmed H., Aleshawi Abdelwahab

Primary Institution: Jordan University of Science and Technology

Hypothesis

This study aims to assess the ophthalmic findings and retinal parameters in women diagnosed with gestational diabetes mellitus (GDM).

Conclusion

The study found that while GDM is not typically associated with diabetic retinopathy, it may still lead to microscopic changes in the retina, suggesting the need for regular eye screenings.

Supporting Evidence

  • Thirty-four women were enrolled in the study.
  • The mean maternal age was 32.7 years.
  • No participant had diabetic retinopathy.
  • Nine eyes had early cataract.
  • Higher levels for the one-hour OGTT were associated with a drop in the CST and total thickness.
  • Women who underwent cesarean section had higher levels of total thickness.
  • Pregnant women with miscarriages had lower macular density on FAF.

Takeaway

Pregnant women with gestational diabetes might have some changes in their eye health, even if they don't have diabetes-related eye disease.

Methodology

The study involved comprehensive ophthalmic examinations and measurements of retinal parameters using optical coherence tomography and fundus autofluorescence in women diagnosed with GDM.

Potential Biases

Potential biases may arise from the observational nature of the study and the exclusion of certain demographics.

Limitations

The small sample size and lack of a control group may limit the generalizability of the findings.

Participant Demographics

Participants were pregnant women aged 20 to 45 diagnosed with GDM.

Statistical Information

P-Value

p = 0.024 for one-hour OGTT and p = 0.030 for total thickness.

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3390/life14121596

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