SHIP-Deficient Dendritic Cells, Unlike Wild Type Dendritic Cells, Suppress T Cell Proliferation via a Nitric Oxide-Independent Mechanism
2011
SHIP-Deficient Dendritic Cells Suppress T Cell Proliferation
publication
Evidence: moderate
Author Information
Author(s): Frann Antignano, Melisa Hamilton, Scott Patterson, Victor Ho, Carla Cohen, Megan K. Levings, Gerald Krystal
Primary Institution: The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Hypothesis
What is the role of SHIP in dendritic cell-induced T cell suppression?
Conclusion
Both SHIP+/+ and SHIP−/− GM-DCs can suppress T cell proliferation, but they use different mechanisms.
Supporting Evidence
- SHIP+/+ and SHIP−/− GM-DCs suppress T cell proliferation equally.
- WT GM-DCs suppress T cell proliferation via nitric oxide production.
- SHIP−/− GM-DCs do not produce nitric oxide and express high levels of arginase 1.
Takeaway
Some immune cells called dendritic cells can stop T cells from growing. There are two types of these cells, and they do it in different ways.
Methodology
The study involved co-culturing different types of dendritic cells with activated T cells to assess their suppressive abilities.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website