White adipose tissues and skeletal muscles as a target of chrysin during the treatment of obesity in rats
2025

Chrysin and Exercise for Obesity Treatment in Rats

Sample size: 40 publication 10 minutes Evidence: moderate

Author Information

Author(s): Hassan Omar S., Megahed Magda A., Ghazal Nesma A.

Primary Institution: Alexandria University

Hypothesis

The study aims to examine the anti-obesity effect of chrysin on high-fat diet-induced obesity in rats and compare its impact to physical activity.

Conclusion

Chrysin treatment significantly reduced weight gain, hyperglycemia, and insulin resistance in obese rats, with the combination of chrysin and swimming showing the best results.

Supporting Evidence

  • Chrysin treatment reduced weight gain and improved insulin sensitivity in obese rats.
  • Swimming was found to be more effective than chrysin alone for weight loss.
  • Combination treatment of chrysin and swimming yielded the best results in managing obesity.

Takeaway

This study shows that chrysin can help rats lose weight and improve their health, especially when combined with swimming.

Methodology

Rats were divided into groups and treated with chrysin, swimming, or both for 8 weeks, followed by biochemical tests and gene expression analysis.

Potential Biases

Potential bias in the selection of treatment groups and the small sample size for each subgroup.

Limitations

The study was conducted only on male rats, which may limit the generalizability of the results to other populations.

Participant Demographics

Young male albino rats, 2 months old.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1038/s41598-024-82820-x

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