HIV-1 Variants in Infected Children and Their Mothers
Author Information
Author(s): Cavarelli Mariangela, Karlsson Ingrid, Zanchetta Marisa, Antonsson Liselotte, Plebani Anna, Giaquinto Carlo, Fenyö Eva Maria, De Rossi Anita, Scarlatti Gabriella
Primary Institution: Fondazione Centro San Raffaele, Milan, Italy
Hypothesis
Does the phenotypic variation of R5 viruses play a role in mother-to-child transmission of HIV-1 and pediatric disease progression?
Conclusion
R5broad viruses can be transmitted and are associated with earlier immunological failure in infected children.
Supporting Evidence
- R5broad viruses were found in a significant proportion of children.
- Children with R5broad viruses experienced faster immunological decline.
- Maternal viral phenotype was predictive of the newborn's viral variant.
Takeaway
Some babies can get a type of HIV that makes them sick faster, and this type often comes from their mothers.
Methodology
Viral isolates from 59 HIV-1 seropositive women and 28 infected newborns were analyzed using U87.CD4 cells expressing various receptors.
Potential Biases
Potential bias due to the study's focus on specific cohorts and lack of diversity in the sample population.
Limitations
The study was limited to Italian subjects and did not include the effects of antiretroviral therapy on outcomes.
Participant Demographics
Participants included 59 HIV-1 seropositive women and 28 infected newborns, primarily from Italy.
Statistical Information
P-Value
0.0260
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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