Urtica dioica L. Leaf Extract and Its Effects on Kidney Health
Author Information
Author(s): Vajic Una-Jovana, Mihailovic-Stanojevic Nevena, Karanovic Danijela, Zivotic Maja, Ivanov Milan, Jovovic Djurdjica, Grujic-Milanovic Jelica, Miloradovic Zoran
Primary Institution: Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade
Hypothesis
Can Urtica dioica L. leaf extract alter nitric oxide and Nrf-2 signaling to prevent oxidative stress and kidney damage in hypertensive rats?
Conclusion
Urtica dioica L. leaf extract significantly reduced blood pressure, oxidative stress, and kidney damage in hypertensive rats, with effects that were dose-dependent and independent of Nrf-2 signaling.
Supporting Evidence
- Urtica dioica leaf extract significantly reduced mean arterial pressure in hypertensive rats.
- All doses of Urtica dioica reduced microalbuminuria compared to control.
- Urtica dioica increased plasma and urine nitric oxide metabolites.
- Urtica dioica treatment improved antioxidant capacity in the kidneys.
- Losartan and Urtica dioica both reduced oxidative stress markers in the kidneys.
Takeaway
This study shows that a plant called Urtica dioica can help lower blood pressure and protect the kidneys in rats with high blood pressure.
Methodology
Spontaneously hypertensive rats were divided into groups and treated with different doses of Urtica dioica leaf extract or losartan for four weeks, followed by measurements of blood pressure, kidney function, and oxidative stress markers.
Limitations
The study was conducted on rats, and results may not directly translate to humans.
Participant Demographics
Male spontaneously hypertensive rats, six months old.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website