Tumour Vascularity and Drug Response in Liver Perfusion
Author Information
Author(s): van Etten B, de Vries M R, van IJken M G A, Lans T E, Guetens G, Ambagtsheer G, van Tiel S T, de Boeck G, de Bruijn E A, Eggermont A M M, ten Hagen T L M
Primary Institution: University Hospital Rotterdam-Daniel den Hoed Cancer Center
Hypothesis
TNF-α causes specific destruction of tumour endothelial cells and thereby induces an increased permeability of tumour vasculature.
Conclusion
The study found that the antitumour effect of TNF-α is correlated with the tumour microvessel density.
Supporting Evidence
- TNF-α in combination with chemotherapy has potent antitumour effects.
- High complete response rates of 75–90% were observed in clinical trials.
- Melphalan concentration in tumour tissue increased significantly when TNF-α was coadministered.
Takeaway
This study shows that a special protein called TNF-α can help cancer medicine work better by making the blood vessels in tumors more open.
Methodology
The study used a rat model with isolated hepatic perfusion to evaluate the effects of TNF-α and melphalan on tumour response.
Limitations
The study was conducted in a rat model, which may not fully replicate human responses.
Participant Demographics
Male inbred WAG/RIJ or Brown-Norway strain rats, weighing 250–300 g.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website