Cug2 is essential for normal mitotic control and CNS development in zebrafish
2011
Cug2 is crucial for brain development in zebrafish
publication
Evidence: moderate
Author Information
Author(s): Kim Hyun-Taek, So Ju-Hoon, Jung Seung-Hyun, Ahn Dae-Gwon, Koh Wansoo, Kim Nam-Soon, Kim Soo-Hyun, Lee Soojin, Kim Cheol-Hee
Primary Institution: Chungnam National University
Hypothesis
CUG2 is essential for normal mitotic control and CNS development in zebrafish.
Conclusion
Cug2 is required for normal mitosis during early neurogenesis and plays a role in neuronal cell maintenance.
Supporting Evidence
- Cug2 is expressed in the proliferating cells of the CNS.
- Knockdown of cug2 leads to apoptosis and neurodegenerative phenotypes.
- cug2-deficient embryos show abnormal spindle formation and chromosome misalignment.
Takeaway
Cug2 helps zebrafish grow their brains properly, and without it, they can get sick and have problems with their brain cells.
Methodology
The study involved isolating a zebrafish homologue of CUG2 and performing morpholino-mediated knockdown to observe effects on CNS development.
Digital Object Identifier (DOI)
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