Differences in Intrinsically Disordered Regions between Yeast Duplicated Proteins
Author Information
Author(s): Montanari Floriane, Shields Denis C., Khaldi Nora, Lustig Arthur J.
Primary Institution: UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin
Hypothesis
Can changes in intrinsically disordered regions after genome duplication create functional divergence in proteins?
Conclusion
The study shows that intrinsic disorder gain and loss in proteins is a mechanism for functional divergence following genome duplication.
Supporting Evidence
- Duplicated genes are significantly more intrinsically disordered than singletons.
- 29% of duplicated genes have more intrinsic disorder than their orthologs.
- 37% of duplicated genes have less intrinsic disorder than their orthologs.
Takeaway
When yeast genes duplicate, they often gain or lose parts that are flexible and can change how they interact with other proteins, which helps them do new things.
Methodology
The study analyzed the gain and loss of intrinsically disordered regions in duplicated proteins using Saccharomyces cerevisiae and Lachancea kluyveri.
Potential Biases
Potential bias in the retention of intrinsically disordered proteins after duplication.
Limitations
The study may overestimate or underestimate the number of intrinsically disordered regions due to the limitations of the prediction tools used.
Participant Demographics
The study focused on yeast species, specifically Saccharomyces cerevisiae and Lachancea kluyveri.
Statistical Information
P-Value
p<2.2e-16
Statistical Significance
p<2.2e-16
Digital Object Identifier (DOI)
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