Improving Piroxicam Dissolution with Microparticles
Author Information
Author(s): Dixit M., Kini A.G., Kulkarni P.K.
Primary Institution: JSS College of Pharmacy, JSS University
Hypothesis
The study aims to improve the dissolution of piroxicam using spray drying and spray chilling methods.
Conclusion
Spray dried microparticles of piroxicam showed improved dissolution compared to spray chilled particles, recrystallized, and pure samples.
Supporting Evidence
- Spray dried microparticles exhibited superior compressibility characteristics compared to pure sample and spray chilled particles.
- The solubility of spray dried microparticles was higher than that of spray chilled particles and pure sample.
- Dissolution profiles showed improved behavior for spray dried microparticles compared to other formulations.
Takeaway
The researchers made tiny particles of a medicine called piroxicam to help it dissolve better in water, which can help it work better in the body.
Methodology
Microparticles were prepared using spray drying and spray chilling techniques, followed by evaluation of their dissolution and solubility.
Limitations
The study was limited by the small scale of preparation and potential degradation of the drug during spray chilling.
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