Low E-cadherin expression in bladder cancer at the transcriptional and protein level provides prognostic information
2000
E-cadherin and Bladder Cancer Prognosis
Sample size: 111
publication
Evidence: high
Author Information
Author(s): Popov Z, Medina S, Gil-Diez de, Lefrere-Belda M-A, Hoznek A, Bastuji-Garin S, Abbou C C, Thiery J P, Radvanyi F, Chopin D K
Primary Institution: Hôpital Henri Mondor, France
Hypothesis
Low E-cadherin expression in bladder cancer provides prognostic information.
Conclusion
Low E-cadherin expression is associated with poor outcomes in bladder cancer patients.
Supporting Evidence
- E-cadherin expression correlated with tumor stage and grade.
- Abnormal E-cadherin levels were linked to poor patient outcomes.
- Survival estimates differed significantly based on E-cadherin expression levels.
Takeaway
This study found that lower levels of a protein called E-cadherin in bladder cancer can mean worse health outcomes for patients.
Methodology
The study analyzed E-cadherin levels in bladder tumors using immunohistochemistry and RT-PCR.
Statistical Information
P-Value
P = 0.001, P = 0.0001, P = 0.0003, P = 0.008, P = 0.03, P = 0.0006
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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