Renal Function and Urinary Excretion of Bisphenol A and Alkylphenols
Author Information
Author(s): You Li, Zhu Xiangzhu, Shrubsole Martha J., Fan Hong, Chen Jing, Dong Jie, Hao Chuan-Ming, Dai Qi
Primary Institution: Vanderbilt University
Hypothesis
Does urinary excretion of bisphenol A (BPA) and alkylphenols (APs) differ by renal function?
Conclusion
Urinary excretion of triclosan, and possibly BPA, decreased with decreasing renal function, with variations by age and sex.
Supporting Evidence
- Urinary BPA excretion decreased with lower eGFR levels.
- 41.7% of participants had normal renal function, while 47.8% had mildly decreased renal function.
- The association between BPA and eGFR was significant in females but not in males.
- Triclosan excretion decreased with decreasing eGFR for both sexes.
- Further studies are needed to understand the mechanisms behind these associations.
Takeaway
People with kidney problems might not get rid of certain chemicals like BPA and triclosan as well as those with healthy kidneys.
Methodology
Data from NHANES 2003–2006 was analyzed, measuring renal function via eGFR and urinary excretion of BPA and APs.
Potential Biases
Potential bias due to dietary changes in participants with known renal diseases.
Limitations
The study is cross-sectional, which limits causal inferences, and relies on self-reported data for some health conditions.
Participant Demographics
Adults aged 20 and older, excluding those with known renal diseases, pregnant or lactating women.
Statistical Information
P-Value
0.04
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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