Orlistat and Weight Loss in Obese Patients with Sleep Disorders
Author Information
Author(s): Mette Svendsen, Serena Tonstad
Primary Institution: Oslo University Hospital, Ullevål Hospital
Hypothesis
Can orlistat help maintain weight loss in obese subjects with sleep-related breathing disorders after initial dietary treatment?
Conclusion
Orlistat led to further weight loss, but dietary compliance decreased over time.
Supporting Evidence
- Weight loss was associated with increased protein intake and reduced saturated fat intake.
- Dietary compliance declined over the year of treatment.
- The high attendance group showed better dietary maintenance than the low attendance group.
Takeaway
This study shows that a medicine called orlistat can help people lose more weight after they have already lost some, but it's hard for them to stick to a healthy diet over time.
Methodology
Participants underwent a 3-month dietary intervention followed by 1 year of orlistat treatment, with dietary intake assessed using a food frequency questionnaire.
Potential Biases
Potential bias due to self-reported dietary intake.
Limitations
The study lacked a control group.
Participant Demographics
63 participants (48 men, 15 women) aged 32-62 years with a mean BMI of 34.6 kg/m2.
Statistical Information
P-Value
0.008
Confidence Interval
95% CI 1.5, 5.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website