New Method for Making Cancer Drug Nanoparticles
Author Information
Author(s): Zu Yuangang, Wang Dan, Zhao Xiuhua, Jiang Ru, Zhang Qi, Zhao Dongmei, Li Yong, Zu Baishi, Sun Zhiqiang
Primary Institution: Northeast Forestry University
Hypothesis
The study aims to develop a targeted drug delivery system for cancer chemotherapy using folic acid conjugated dextran nanoparticles loaded with camptothecin.
Conclusion
The study successfully developed tumor-targeted nanoparticles with a mean particle size of 182.21 nm and demonstrated effective drug encapsulation and loading efficiencies.
Supporting Evidence
- The mean particle size of the nanoparticles was optimized to 182.21 nm.
- Drug encapsulation efficiency was found to be 62.13%.
- Loading efficiency of the nanoparticles was 36.12%.
Takeaway
Researchers created tiny particles that can deliver a cancer drug directly to tumors, making it more effective and reducing side effects.
Methodology
The nanoparticles were prepared using a supercritical antisolvent technique and characterized using various methods including SEM, FT-IR, DSC, and XRD.
Digital Object Identifier (DOI)
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