The Role of Platelets in Alzheimer's Disease
Author Information
Author(s): Hayder M. Al‐kuraishy, Ghassan M. Sulaiman, Hamdoon A. Mohammed, Dawood Retaj A., Ali K. Albuhadily, Ali I. Al‐Gareeb, Mosleh M. Abomughaid, Daniel J. Klionsky
Hypothesis
Activated platelets contribute to the pathogenesis of Alzheimer's disease by increasing amyloid peptide accumulation.
Conclusion
Targeting activated platelets may reduce Alzheimer's disease neuropathology.
Supporting Evidence
- Activated platelets are implicated in the pathogenesis of Alzheimer's disease.
- Platelets can produce amyloid beta, which contributes to Alzheimer's pathology.
- Targeting platelet activation may present a new therapeutic strategy for Alzheimer's disease.
Takeaway
This study talks about how platelets, which are normally helpful for our brain, can become harmful in Alzheimer's disease and make things worse. If we can find ways to calm these platelets down, it might help people with Alzheimer's.
Methodology
This review examines existing literature on the role of activated platelets in Alzheimer's disease pathology.
Limitations
The review does not estimate platelet activity in different stages of Alzheimer's disease or in relation to anti-Alzheimer treatments.
Digital Object Identifier (DOI)
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