Myocardial Oxygenation and Perfusion in Syndrome X
Author Information
Author(s): Karamitsos Theodoros D, Arnold Ranjit, Pegg Tammy J, Francis Jane, Howells Ruairidh K, Robson Matthew D, Neubauer Stefan, Jerosch-Herold Michael, Selvanayagam Joseph B
Primary Institution: OCMR Unit, University of Oxford, Oxford, UK
Hypothesis
Do patients with cardiac Syndrome X show evidence of myocardial ischemia during vasodilator stress compared to normal volunteers?
Conclusion
Patients with Syndrome X have no reduction of absolute perfusion or impairment in oxygenation during vasodilatory stress.
Supporting Evidence
- All subjects successfully completed the study protocol.
- There were no differences in LV volumes and ejection fraction between patients and normal controls.
- No subject had evidence of late gadolinium enhancement.
- Myocardial blood flow at stress, BOLD signal change, and coronary flow reserve measurements showed no significant differences in Syndrome X patients and controls.
- Oxygenation and perfusion measurements per coronary territory were also similar between the two groups.
Takeaway
This study found that people with Syndrome X have normal blood flow and oxygen levels in their hearts, just like healthy volunteers.
Methodology
18 patients with Syndrome X and 14 normal volunteers underwent CMR scanning at 3 Tesla to assess myocardial function, perfusion, and oxygenation.
Limitations
The study may reflect differences in patient population and CMR methodology compared to other studies.
Participant Demographics
18 patients (15 women) with Syndrome X and 14 age and sex-matched normal volunteers (11 women).
Digital Object Identifier (DOI)
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