Genetic Factors in Aging and Longevity Among Older Adults
Author Information
Author(s): Chen Siting, Nagel Corey L, Lapidus Jodi, Quiñones Ana
Primary Institution: OHSU-PSU School of Public Health
Hypothesis
The study aims to identify genetic characteristics of multi-dimensional aging and longevity by examining the association of longevity polygenic risk scores with multi-domain aging trajectories and long-term survival.
Conclusion
The study found that older adults with minimal impairment and low multimorbidity had a significantly higher proportion of long-lived individuals, particularly among Non-Hispanic White and Black adults.
Supporting Evidence
- The study analyzed data from the Health and Retirement Study (HRS) spanning from 1998 to 2016.
- Four distinct multi-domain trajectory groups were identified based on health and aging characteristics.
- The long-lived group had a higher proportion of individuals with high longevity polygenic risk scores.
Takeaway
This study looked at how genetics might affect how well older people age and how long they live, finding that those with fewer health problems tend to live longer.
Methodology
Group-based trajectory modeling was used to identify distinct groups of older adults based on their aging trajectories across four domains.
Participant Demographics
Older Non-Hispanic White and Non-Hispanic Black adults, with 14.0% being Non-Hispanic Black.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website