Neuregulin-1 and Type A Behavior
Author Information
Author(s): Helena M Service, Mirka Hintsanen, Taina Hintsa, Terho Lehtimäki, Olli T Raitakari, Jorma S Viikari, Liisa Keltikangas-Järvinen
Primary Institution: Department of Psychology, University of Helsinki, Finland
Hypothesis
NRG1 is hypothesized to be associated with Type A behavior.
Conclusion
The study identified a SNP in NRG1 that predicts Type A behavior.
Supporting Evidence
- Type A behavior was associated with NRG1 genotype.
- Carriers of genotype CC scored lower on Type A compared to others.
- The study followed participants over nine years.
Takeaway
This study found that a specific gene variant is linked to a personality type that can affect heart health.
Methodology
The study examined the association between Type A behavior and the SNP8NRG221533 of the NRG1 gene in a population-based study.
Potential Biases
Women were somewhat overrepresented in the sample.
Limitations
Reliabilities for Type A measures were moderate, and the association was specific to the Framingham Type A measure.
Participant Demographics
Of the 631 participants, 276 (43.7%) were men and 355 (56.3%) were women.
Statistical Information
P-Value
p = .01 for trait-related Type A behavior
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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