Developing a Core Outcome Set for Leptospirosis Trials
Author Information
Author(s): Lee Nathaniel, Smith Chris, Bailey Robin, Ariyoshi Koya, Smith Sarah, Black Nick, Edwards Tansy
Primary Institution: London School of Hygiene & Tropical Medicine
Hypothesis
The study aims to develop a core outcome set (COS) for leptospirosis research to standardize outcome measures in clinical trials.
Conclusion
The establishment of a core outcome set will help harmonize leptospirosis treatment research and improve the quality of evidence for future clinical trials.
Supporting Evidence
- Leptospirosis is a significant public health concern due to its global distribution and high mortality.
- The study aims to standardize outcome measures to improve the comparability of clinical trials.
- Current treatment research for leptospirosis lacks established outcome measures.
Takeaway
This study is trying to create a list of important things to measure when treating leptospirosis, so that all doctors and researchers can agree on what to look for.
Methodology
The study will use a systematic review, qualitative interviews, a Delphi survey, and a consensus meeting to develop the COS.
Potential Biases
There may be risks of bias in outcome reporting due to the subjective nature of qualitative data collection.
Limitations
The study may face challenges in participant recruitment and achieving consensus across diverse stakeholder groups.
Participant Demographics
Participants will include healthcare providers, researchers, policymakers, and individuals affected by leptospirosis.
Digital Object Identifier (DOI)
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