The Aqueous Soluble Polyphenolic Fraction of Psidium guajava Leaves Exhibits Potent Anti-Angiogenesis and Anti-Migration Actions on DU145 Cells
2011
Guava Leaf Extract Shows Anti-Cancer Effects on Prostate Cells
publication
Evidence: high
Author Information
Author(s): Peng Chiung-Chi, Peng Chiung-Huei, Chen Kuan-Chou, Hsieh Chiu-Lan, Peng Robert Y.
Primary Institution: China Medical University
Hypothesis
Can the aqueous extract of Psidium guajava leaves be used as an anti-tumor chemopreventive agent?
Conclusion
The aqueous extract of guava leaves has strong anti-cancer effects on prostate cancer cells by inhibiting cell viability, migration, and angiogenesis.
Supporting Evidence
- The IC50 of guava leaf extract for DU145 cells was approximately 0.57 mg/ml.
- Guava leaf extract effectively inhibited the expressions of VEGF, IL-6, and IL-8 cytokines.
- PE downregulated MMP-2 and MMP-9 while activating TIMP-2.
- Cell migration was suppressed by guava leaf extract in a dose-responsive manner.
Takeaway
Guava leaves can help fight cancer by stopping cancer cells from growing and spreading.
Methodology
The study used various assays including MTT, ELISA, western blot, and wound scratch assays to evaluate the effects of guava leaf extract on prostate cancer cells.
Statistical Information
P-Value
0.57 mg/ml
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website