Bone Changes Around Titanium Implants in Ovariectomized Rats
Author Information
Author(s): Kivanc Akca, Ebru Sarac, Ugur Baysal, Mete Fanuscu, Ting-Ling Chang, Murat Cehreli
Primary Institution: Hacettepe University
Hypothesis
Using transmitted low-magnitude high-frequency mechanical vibration (MECHVIB) could facilitate better bone response around titanium implants compared to pulsed electromagnetic field (PEMF) stimulation in osteoporotic rats.
Conclusion
Biophysical stimulation remarkably enhances bone volume around titanium implants placed in osteoporotic rats, with low-magnitude high-frequency MECHVIB being more effective than PEMF.
Supporting Evidence
- Mean relative bone volume around MECHVIB-stimulated implants was significantly higher than control.
- Differences in trabecular thickness and separation were similar across all groups.
- Trabecular number was significantly higher in MECHVIB-stimulated implants compared to control.
Takeaway
This study found that special vibrations can help bones grow better around implants in rats with weak bones.
Methodology
Fifteen ovariectomized rats were divided into three groups: a control group and two test groups receiving different biophysical stimulations (PEMF and MECHVIB) for two weeks, followed by microCT analysis of bone around the implants.
Limitations
The study was limited to a small sample size and only evaluated short-term effects of the treatments.
Participant Demographics
12-week old Sprague-Dawley female rats.
Statistical Information
P-Value
0.000
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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