How SERPINE1 Affects Macrophage Polarization in Gastric Cancer
Author Information
Author(s): Ye Zhenzhen, Yi Jianfeng, Jiang Xiangyan, Shi Wengui, Xu Hao, Cao Hongtai, Qin Long, Liu Lixin, Wang Tianming, Ma Zhijian, Jiao Zuoyi
Primary Institution: The Second Hospital of Lanzhou University
Hypothesis
This study aims to identify a dual-function target in gastric cancer cells that drives both malignant phenotypes and M2 macrophage polarization.
Conclusion
SERPINE1 promotes gastric cancer progression and M2 polarization through the regulation of exosomal let-7 g-5p transfer via the JAK2/STAT3 signaling pathway.
Supporting Evidence
- SERPINE1 was identified as a highly expressed mRNA in gastric cancer tissues and cells.
- SERPINE1 overexpression in gastric cancer cells promoted tumor growth and M2 macrophage polarization.
- Exosomal let-7 g-5p internalized by macrophages downregulated SOCS7 protein levels, leading to STAT3 hyperactivation.
Takeaway
SERPINE1 helps cancer cells grow and makes certain immune cells, called M2 macrophages, more active, which can help the cancer spread.
Methodology
The study used transcriptomic and clinical data, single-cell sequencing, and various in vitro and in vivo experiments to analyze the role of SERPINE1 in gastric cancer and macrophage polarization.
Participant Demographics
Patients diagnosed with gastric cancer who underwent surgical resection.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website