Redox regulation of proteostasis
2024
Redox Regulation of Proteostasis
publication
Evidence: high
Author Information
Author(s): Duong Long Duy, West James D., Morano Kevin A.
Primary Institution: McGovern Medical School, The University of Texas Health Science Center at Houston
Hypothesis
How do cells respond to oxidative stress and maintain protein homeostasis?
Conclusion
Cells employ various mechanisms, including blocking protein translation and activating chaperones, to mitigate oxidative damage and maintain proteostasis during oxidative stress.
Supporting Evidence
- Cells block the translation of new proteins immediately after oxidative stress.
- Chaperones shift from folding to holding roles to prevent protein aggregation.
- Gene expression is adapted to increase antioxidant enzyme levels during oxidative stress.
- Proteins damaged by oxidative stress are targeted for degradation through autophagy and proteasomal pathways.
Takeaway
When cells face stress from things like pollution or aging, they stop making new proteins and focus on fixing the ones that are broken to keep everything working well.
Digital Object Identifier (DOI)
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